Resveratrol Supplements did not benefit Healthy Women

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(Best Syndication News) - A study on healthy middle-aged women found no benefit gained by taking resveratrol supplements, a compound found in red wine. The study was reported in the October 25 online edition of Cell Metabolism.

Previous research had suggested that resveratrol in red wine could help reduce heart disease risk and increase lifespan. People have been taking resveratrol in hopes of better health. The U.S. resveratrol supplement business has grown into a $30 million a year industry. People take supplements because they would have to drink large amounts of red wine to gain the benefit – at least that was the conventional wisdom. Researchers from Washington University School of Medicine in St. Louis wanted to see if taking resveratrol supplements was beneficial to otherwise healthy women.

To explore this, senior investigator Samuel Klein, MD, director of Washington University's Center for Human Nutrition, and colleagues, had 29 post-menopausal women that were considered healthy and did not have type-2 diabetes participate in the study. Fifteen women were assigned to take a 75 milligram dose of a resveratrol supplement daily, while the remaining fourteen women received a placebo. The women took the supplement or placebo pills for 12 weeks.

The researchers measured the womens’ insulin sensitivity and the rate at which glucose entered their muscle. They accomplished this by infusing insulin into the women’s bodies and then measuring the metabolic response to the different doses. The researchers also took small samples of muscle and fat tissue from the women to see if there was any benefit in the cells. They did not find any changes in the metabolism signaling pathways.

Klein said that previous research with resveratrol involved people with diabetes, obesity, and metabolic conditions. They also may have been elderly with impaired glucose tolerance. The benefits may remain with those people who have metabolic abnormalities, he explained.

Klein suggested that another compound could exist in red wine that might be associated with the reduced risk for developing heart disease and type-2 diabetes. Resveratrol, possibly combined with other compounds found in red wine, might offer the health benefits.

By: Marsha Quinn
Health Reporter

Ref: Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB, Gu C, Kunz I, Fanelli FR, Patterson BW, Klein S. Resveratrol supplementation does not improve metabolic function in non-obese women with normal glucose tolerance. Cell Metabolism vol 16, published on line Oct. 25, 2012

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