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Allergy Response Caused By Lack of Custom T-Cells – Treg Regulatory Cell Responsible For Remembering Allergens
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(Best Syndication News) Researchers say that custom T cells are responsible for immune response (see the videos below). These specialized T-cells are programmed to remember foods, chemicals and other substances. Some of these substances are “remembered” as harmless and allowed to pass.
Scientists in New York have identified a class of these immune cells that block allergic reactions. Things can go awry when these T-cells are not created to specific substances and the lack of them may trigger an allergic response. These regulatory cells received their instructions and are created by a gene called Foxp3. Whenever we eat or inhale anything for the first time, a memory is created of that substance.
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These memories are important because they tell the body not to mount an allergic response. Maria A. Curotto de Lafaille, Ph.D., Associate Research Scientist at NYU Langone Medical Center explained how this works.
"We don't become allergic to lots of things—we eat all kinds of things, we breathe all kinds of things, and what prevents us from developing allergies is that we make regulatory T cells, which specifically recognize this allergen," Langone said. "Every time we don't react to something or don't become allergic, it's not because nothing is happening. It's because something very important is happening: We're making these cells."
The Foxp3-directed regulatory T cells (Treg) are produced in the mucosal tissue which line the respiratory and digestive tracts. New ones are constantly being tailor made to substances we come in contact with and they remain there to prevent allergic reactions in the future. If a person is unable to make these T-cells for whatever reason, they become allergic.
This new research was done on mice at the New York University Langone Medical Center, and their findings were published in the July 18, 2008 issue of the journal Immunity.
See what others are saying and join the discussion at our Forum
By Marsha Quinn
Best Syndication News Health Writer
Food Allergies
CO2 For Allergies
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Important: The material on Best Syndication is for informational purposes only and is not meant to be advice. Authors may have or will receive monetary compensation from the company's product/s mentioned. You should always seek professional advice before making any legal, financial or medical decisions and this website cannot substitute or replace any trained professional consultation. |
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