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(Best Syndication) A meta-study released April 17, 2007 involving 20 trials comparing chondroitin to a placebo or no treatment found that there was little beneficial effect on knee or hip pain caused by arthritis. The new research released in the Annals of Internal Medicine suggests that chondroitin use should "be discouraged."
A previous study released in the New England Journal of Medicine on February 22, 2006 indicated that a small subgroup of study participants with moderate-to-severe pain showed “significant relief” using glucosamine plus chondroitin sulfate.
The new 20 trial meta-analysis involving 3,846 patients revealed a high degree of heterogeneity among the trials (I2 = 92%). They found that trials that were not analyzed according to the intention-to-treat principle showed larger effects in favor of chondroitin.
The larger trials showing sound methodology indicated the symptomatic benefit of chondroitin is minimal or nonexistent.
By Marsha Quinn
Best Syndication Health Writer
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